ACE, angiotensin I converting enzyme, 1636

N. diseases: 101; N. variants: 18
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker phenotype CTD_human Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period. 25322899 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders. 22808171 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population. 22688325 2012
CUI: C0011071
Disease: Sudden death
Sudden death 		0.300 Biomarker phenotype CTD_human Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. 15331425 2004
CUI: C0848676
Disease: Subfertility, Male
Subfertility, Male 		0.300 Biomarker phenotype CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker disease CTD_human Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. 22191573 2012
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.320 Biomarker group CTD_human Expression of the local angiotensin II system in gastric cancer may facilitate lymphatic invasion and nodal spread. 18059164 2007
CUI: C1318973
Disease: Staphylococcus aureus infection
Staphylococcus aureus infection 		0.300 Biomarker disease CTD_human Activity of serum angiotensin converting enzyme in septic pigs treated with intrapulmonary corticosteroid. 8186310 1994
CUI: C0038160
Disease: Staphylococcal Infections
Staphylococcal Infections 		0.300 Biomarker group CTD_human Activity of serum angiotensin converting enzyme in septic pigs treated with intrapulmonary corticosteroid. 8186310 1994
CUI: C1175175
Disease: Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome 		0.320 Biomarker disease CTD_human ACE1 polymorphism and progression of SARS. 15381116 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET The present study aimed at detecting the incidence of ACE gene I/D polymorphism in patients with schizophrenia living in the Eskisehir region (Turkey) and also at determining whether this illness could be associated to ACE gene I/D polymorphism and serum ACE concentrations. 21158679 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia. 25694211 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET As SZ and BD have some susceptibility genes in common and since unaffected first-degree relatives of these patients carry a high likelihood of these susceptibility genes, we aimed to elucidate the role of angiotensin-converting enzyme (ACE) genetic variants in patients with SZ, BD and their first-degree relatives. 20010451 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and first-episode patients with schizophrenia in a Chinese Han population. 24615782 2014
CUI: C0035242
Disease: Respiratory Tract Diseases
Respiratory Tract Diseases 		0.300 Biomarker group CTD_human Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants. 14657821 2003
CUI: C2678367
Disease: Renal Tubular Dysgenesis With Choanal Atresia And Athelia
Renal Tubular Dysgenesis With Choanal Atresia And Athelia 		0.300 GermlineCausalMutation disease ORPHANET Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis. 22095942 2012
CUI: C2678367
Disease: Renal Tubular Dysgenesis With Choanal Atresia And Athelia
Renal Tubular Dysgenesis With Choanal Atresia And Athelia 		0.300 GermlineCausalMutation disease ORPHANET Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. 16116425 2005
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.320 Biomarker phenotype CTD_human Other characteristics of patients presenting with severe PH were poor compliance to ERT (4/9 patients) or no ERT (5/9 patients), a family history of a sib with GD and PH (2/2 patients), an excess of ACE I allele (OR 2.3, 95% CI 1.1-4.9, P=0.034) and an excess of non-N370S GBA mutation (OR 6.0, 95% CI 1.1-33, P=0.003). 12359135 2003
CUI: C0033941
Disease: Psychoses, Substance-Induced
Psychoses, Substance-Induced 		0.300 Biomarker disease CTD_human Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease. 17196621 2007
CUI: C0033937
Disease: Psychoses, Drug
Psychoses, Drug 		0.300 Biomarker disease CTD_human Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease. 17196621 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 Biomarker group CTD_human Effects of ACE I/D polymorphism on prostate cancer risk, tumor grade and metastatis. 17465223 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. 30820047 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. 10643899 1999